Enzymatic hydrolysis of the β–β amide linkage in poly-β-aspartate
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منابع مشابه
Enzymatic hydrolysis of poly-DL-lysine.
The c o n d e n s a t io n o f racemic ly s in e to p o ly -D L ly s in e produces a great number o f d is t in guishable molecules. Following merely statistical reasoning the number o f “pure peptides“ — consisting of only one sort of enantiomers — should be extremely low. The hydrolysis of polyD L -ly s in e by pronase a n d t a k a -d ia s ta s e shows that a content of about 3% “pure“ pol...
متن کاملThe synthesis and enzymatic hydrolysis of poly-D-lysine.
In studies of the inhibition in viva of animal viruses by poly-n-lysine, Rubini et al. (1) and Green et al. (2-4) obtained data which suggested that poly-L-lysine is hydrolyzed by the proteolytic enzymes of the allantoic fluid, and that this enzymatic hydrolysis may limit its biological activity. The enzymatic hydrolysis of poly-n-lysine was reported by Katchalski (5) and by Waley and Watson (6...
متن کاملMicrobial and enzymatic hydrolysis of poly(aspartic acid)
The microbial and enzymatic hydrolysis of poly(aspartic acid) (PAA) has been reviewed. Two PAA-degrading bacteria (Pedobacter sp. KP-2 and Sphingomonas sp. KT-1) were isolated from flesh river water. Pedobacter sp. KP-2 hydrolyzed PAA of high molecular weights over 5000. Sphingomonas sp. KT-1 hydrolyzed only PAA of low molecular weights (<5000), while the cell extract could hydrolyze high-molec...
متن کاملDNA-Catalyzed Amide Hydrolysis.
DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro selection. However, for certain reactions this identification has not been achieved. One important example is DNA-catalyzed amide hydrolysis, for which a previous selection experiment instead led to DNA-catalyzed DNA phosphodiester hydrolysis. Subsequent efforts in which the selection strategy deliberatel...
متن کاملThe enzymatic hydrolysis of glucuronolactone.
Studies over the past 20 years on the metabolism of carbohydrates have implicated glucuronolactone as a precursor of several compounds of physiological interest; namely, L-xylulose (1, 2), ascorbic acid (3, 4), and furan2,5-dicarboxylic acid (5). Studies in viva from two laboratories, demonstrating that mammalian tissues can oxidize glucuronolactone to CO2 (6) but fail to oxidize glucuronic aci...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2014
ISSN: 2053-2733
DOI: 10.1107/s2053273314083508